Common Supplement Shows Concerning Link to Heart Failure

Concerns Raised Over Long-Term Melatonin Use

Recent research on a widely used sleep aid has sparked concern among some scientists regarding its prolonged use. A study involving over 130,000 adults with insomnia, not yet peer-reviewed, suggests that individuals prescribed melatonin for more than a year face increased heart risks.

Increased Risk of Heart Failure and Mortality

The analysis showed that long-term melatonin users had an 89% higher risk of heart failure within five years. Additionally, these individuals were twice as likely to die from any cause compared to those not prescribed melatonin.

Study Limitations and Health Recommendations

These findings are preliminary and do not alter current health guidelines. The study does not confirm that melatonin, the fourth most popular natural supplement in the US, directly causes these health issues.

The results suggest longer-term melatonin use requires further investigation to confirm safety.

Current Understanding of Melatonin Safety

Melatonin is generally regarded as safe and well-tolerated for short-term use, typically 1 to 2 months, in people who are not pregnant or breastfeeding. However, research on its effects beyond this period remains limited.

Need for Further Research

As melatonin’s popularity continues to rise, many experts call for more thorough studies to understand its long-term impact on health.

The new findings were presented at the American Heart Association's Scientific Sessions.

Related

Author’s summary: Preliminary data links long-term melatonin use with higher heart failure risk and mortality, highlighting an urgent need for more research on its safety beyond short-term use.

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ScienceAlert ScienceAlert — 2025-11-07

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