Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

New research indicates that individuals with insomnia taking melatonin supplements for over a year face an increased risk of heart failure compared to those who do not use this common sleep aid.

The study found that long-term melatonin users were more likely to receive a heart failure diagnosis, be hospitalized due to this condition, or die from any cause.

Study Presentation and Status

This preliminary research is scheduled for presentation at the American Heart Association’s Scientific Sessions 2025 in New Orleans. It has not yet undergone peer review or been published in a scientific journal.

Researcher Insights and Concerns

“The study does not prove a direct cause-and-effect link between melatonin supplements and heart failure risks.”

Nevertheless, the findings raise concerns about the safety of using melatonin over long periods, indicating a need for further cardiovascular safety evaluations.

Supplement Regulation and Usage

Many melatonin supplements are available over-the-counter without requiring a prescription.

These products are not regulated.
Users often take them without medical supervision.

“Melatonin supplements may not be as harmless as commonly assumed.”

Author's Summary

Long-term melatonin use in people with insomnia may raise heart failure risk, highlighting the need for regulated guidance and further cardiovascular safety research.

Healthline — 2025-11-05