Think melatonin is safe? New research reveals a hidden heart risk

Long-Term Melatonin Use and Heart Risks

Chronic use of melatonin for sleep issues may pose serious risks to heart health. Recent research indicates that individuals using melatonin for extended periods have nearly double the risk of death and are 3.5 times more likely to be hospitalized due to heart failure.

Study Findings Presented at AHA 2025

A preliminary study shared at the American Heart Association's Scientific Sessions 2025 revealed that adults with chronic insomnia taking melatonin for a year or more showed increased rates of heart failure, hospitalizations related to heart failure, and overall mortality compared to non-users.

This research was highlighted during the AHA event held November 7-10 in New Orleans, a major forum for updates in cardiovascular science and clinical research.

Understanding Melatonin

Melatonin is a hormone produced by the pineal gland that helps regulate the body’s sleep-wake cycle. Its levels rise in darkness and decrease in daylight.

Synthetic melatonin, chemically identical to the natural hormone, is commonly used to manage insomnia and jet lag. In many countries, including the U.S., melatonin supplements are available over the counter.

Regulatory Considerations

Because melatonin supplements are not regulated by the U.S. Food and Drug Administration, there can be significant variability in their purity and dosage.

"Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement."

Summary: Prolonged melatonin use may significantly increase risks of heart failure and mortality, underscoring the need for caution with long-term supplementation.

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ScienceDaily ScienceDaily — 2025-11-05

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