NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT. Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since Week 3, picks in this story are up 2.16 units.
Week 6 Predictions
This week, we explore 3 bold predictions for the NFL. One notable consideration is fading the Colts offense, despite their current average of 3.39 points per drive, which would be the highest this century if maintained all season.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Author's summary: NFL Week 6 picks and predictions.
- 3 plus-money bets to consider for Week 6
- Last week's bold predictions resulted in a +1.17 unit gain
- Picks in this story are up 2.16 units since Week 3
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