Long-term use of melatonin supplements to support sleep may have negative health effects

Long-term Melatonin Use Linked to Negative Health Effects

A review of health records spanning five years involving over 130,000 adults with insomnia who used melatonin supplements for at least a year found an increased likelihood of heart failure diagnosis, hospitalization for heart failure, and death from any cause in chronic insomnia patients.

Study Overview

This preliminary research was presented at the American Heart Association’s Scientific Sessions 2025, held in New Orleans from November 7 to 10, a major global event showcasing the latest advances in cardiovascular science.

Melatonin and Its Use

Melatonin, a hormone naturally produced by the pineal gland, regulates the body’s sleep-wake cycle, increasing during darkness and decreasing in daylight. Synthetic melatonin, chemically identical to the natural hormone, is frequently used to treat insomnia and jet lag.

Melatonin supplements are widely available over the counter in many countries, including the United States.
In the U.S., these supplements do not require government approval to verify quality and consistency.
Consequently, the strength and purity can vary significantly between brands.

“Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia.”

Implications

This study suggests caution in the prolonged use of melatonin supplements for sleep support due to potential cardiovascular risks, highlighting the need for further research.

Author’s summary: Prolonged melatonin use to aid sleep may pose heart health risks, emphasizing the importance of careful consideration and further investigation.

www.heart.org — 2025-11-04

Long-term Melatonin Use Linked to Negative Health Effects

Study Overview

Melatonin and Its Use

Implications

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