The Role of PDTs in Clinical Practice | AJMC

The Role of PDTs in Clinical Practice

Panelists discuss how prescription digital therapeutics are currently used in clinical practice, noting that while none are yet approved for schizophrenia, CT-155 shows promise in phase 3 trials, and existing PDTs like Rejoyn for depression demonstrate the potential for technology-based interventions.

Currently, patients with schizophrenia do not have access to FDA-approved prescription digital therapeutics, though promising developments are emerging.

One digital therapeutic (CT-155) has received breakthrough designation and completed phase 3 clinical trials, with results expected to be presented to the mental health community soon.

For patients with depression, clinicians can prescribe reSET, an approved digital therapeutic that provides cognitive behavioral therapy as an adjunct to medications, demonstrating the potential for similar applications in schizophrenia treatment.

Clinical experience with existing PDTs reveals both opportunities and challenges for patient care.

Prescription digital therapeutics demonstrate potential for technology-based interventions.

Author summary: PDTs show promise in clinical practice for schizophrenia and depression treatment.

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The American Journal of Managed Care The American Journal of Managed Care — 2025-10-14

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